SHIELDS LAB

Our research aims to address key unanswered questions of how tumour stroma regulates immune activity from early stages of disease and covers three main areas:

 

• Identifying the mechanisms of stromal-mediated immune dysfunction from the earliest step of tumour development

 

• Understanding how stromal cells operate in tumour draining lymph nodes as a tumour develops

 

• Identifying mechanisms of resistance, treatment responses and novel therapeutic strategies to target the tumour stroma 

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Our goal is to exploit this knowledge towards the development of methods for early detection, risk stratification, therapy, and ultimately patient benefit