SHIELDS LAB
@KCL
PUBLICATIONS
REVIEWS
Hafsa Munir, Corrado Mazzaglia, Jacqueline D Shields (2020). Stromal regulation of tumour-associated lymphatics. 161-162:75-89. Advanced Drug Delivery Reviews.
James O Jones, William M Moody, Jacqueline D Shields (2020). Microenvironmental modulation of the developing tumour: an immune-stromal dialogue. Molecular Oncology. Aug 2. doi: 10.1002/1878-0261.12773.
PREPRINTS
Luisa Pedro, Jacqueline D. Shields. Podoplanin interaction with caveolin-1 promotes tumour cell migration and invasion.
Biorxiv, doi: https://doi.org/10.1101/488304
Corrado Mazzaglia, Yaqi Sheng, Leonor Nunes Rodrigues, Iek Man Lei, Jacqueline D. Shields* and Yan Yan Shery Huang*.Simulating the Tumor Microenvironment for Immune Cell Interactions via Deployable Extrusion Bioprinting. Biorxiv.
*Co-corresponding Author
SELECTED PAPERS
Grant D Stewart, Sarah J Welsh, Stephan Ursprung, Ferdia A Gallagher, James O Jones, Jacqueline D. Shields, Christopher G Smith, Anne Warren, Axel Bex, Ekaterini Boleti, Tim Eisen, Kate Fife, Abdel Hamid, Alexander Laird, Steve Leung, Jahangeer Malik, Iosif A Mendichovszky, Faiz Mumtaz, Grenville Oades, Antony CP Riddick, Balaji Venugopal, Michelle Welsh, Kathleen Riddle, Lisa EM Hopcroft, Robert J Jones, on behalf of the NAXIVA Trial Group. (2022). A phase II study of neoadjuvant axitinib for reducing extent of venous tumour thrombus in clear cell renal cell cancer with venous invasion (NAXIVA). Accepted. Brit J Cancer.
Angela Riedel, Jonathan Swietlik, David Shorthouse, Tim Young, Ana. S. H. Costa, Sarah Davidson, Luisa Pedro, Benjamin A Hall, Christian Frezza, Jacqueline D. Shields. (2022) Tumour pre-conditioning of draining lymph node stroma by lactic acid. 10 (4): 482–497. Cancer Immunol Res.
Hafsa Munir, James O. Jones, Carla P. Martins, Tobias Janowitz, Markus Hoffmann, Maximilien Euler, Carla P. Martins, Sarah J. Welsh & Jacqueline D. Shields (2021). Stromal Amyloid β drives Neutrophil extracellular trap formation to augment tumour growth. 12, 683, Nature Communications.
Martijn J. Schuijs, Shaun Png, Arianne C. Richard, Anastasia Tsyben, Gregory Hamm, Julie Stockis, Celine Garcia, Silvain Pinaud, Ashley Nicholls, Xavier Romero Ros, Jing Su, Matthew D. Eldridge, Angela Riedel, Eva Serrao, Hans-Reimer Rodewald, Matthias Mack, Jacqueline D Shields, E. Suzanne Cohen, Andrew N.J. McKenzie, Richard J.A. Goodwin, Kevin M. Brindle, John C. Marioni & Timotheus Y.F. Halim (2020). ILC2-driven innate immune checkpoint mechanism antagonizes NK cell antimetastatic function in the lung. 3 Aug. Nat Immunol. https://doi.org/10.1038/s41590-020-0745-y.
Bidesh Mahata, Jhuma Pramanik, Louise van der Weyden, Gozde Kar, Angela Riedel, Ed Ryder, Graham Duddy, David J. Adams, Jacqueline D Shields* and Sarah A Teichmann*(2020). Tumors induce de novo steroid biosynthesis in T cells to evade immunity. Nature Communications. Volume 11, Article number: 3588
* Co-corresponding
Sarah Davidson, Mirjana Efremova, Angela Riedel, Bidesh Mahata, Roser Vento-Tormo, Jhuma Pramanik, Gozde Kar, Jani Huuhtanen, Jacqueline D. Shields*, Sarah A. Teichmann* (2020). Single cell RNA sequencing reveals a dynamic stromal niche within the evolving tumour microenvironment. Cell Reports. 31, 107628.
* Co-corresponding
Luisa Pedro, Quentin Harmer, Eric Mayes, Jacqueline D. Shields (2019). Rapid sentinel lymph node diagnosis using carboxydextran-coated superparamagnetic iron nanoparticle without long-term immune functional implications. Small. 15(20): 1900224.
Ricardo Miragaia, Tomás Gomes, Agnieszka Chomka, Laura Jardine, Angela Riedel, Ahmed N Hegazy, Ida Lindeman, Guy Emerton, Thomas Krausgruber, Jacqueline Shields, Muzlifah Haniffa, Fiona Powrie, Sarah A Teichmann (2019). Single cell transcriptomics of regulatory T cells reveals trajectories of tissue adaptation. 5 Feb. Immunity. DOI:https://doi.org/10.1016/j.immuni.2019.01.001
David Shorthouse, Angela Riedel, Emma Kerr, Luisa Pedro, Dora Bihary, Shamith Samarajiwa, Carla Martins, Jacqueline Shields*, Benjamin A Hall* (2018). Role of stromal osmoregulation in cellular transformation in cancer and disease. Nature Communications. 9(1):3011
* Co-corresponding
Tamara Muliaditan, Mary Okesola, Jonathan Caron, Mirella Georgouli, Peter Gordon, Sharanpreet Lall, Desislava Kuzeva, Luisa Pedro, Jacqueline D. Shields, Cheryl E. Gillett, Sandra S. Diebold, Victoria Sanz-Moreno, Tony Ng, Esther Hoste, and James N. Arnold (2018). Tumour-associated macrophages exploit an innate wound healing response to facilitate metastasis. Nature Communications. 9(1):2951.
M Lakins, E Ghorani, H Munir, C Martins, JD Shields (2018). Cancer-associated Fibroblasts Provide Immune Protection to Tumor Cells via Antigen-Specific Deletion of CD8+ Cytotoxic T Cells. Nature Communications. 9: 948.
Riedel A, Shorthouse D, Haas L, Hall BA, Shields J. (2016) Tumor-induced stromal reprogramming drives lymph node transformation. Nat Immunol. 17(9): 1118–1127.
JD Shields (2011). Lymphatics: at the interface of immunity, tolerance and tumour metastasis. Invited review article. Microcirculation. 18(7):517-31
JD Shields, IC Kourtis, AA Tomei, J Roberts, MA Swartz (2010). Induction of lymphoid-like stroma and immune escape by tumors that express the chemokine CCL21. Science. 7;328(5979):749-52
JD Shields, ME Fleury, C Yong, AA Tomei, GJ Randolph, MA Swartz (2007). Tumor cell homing to lymphatics is mediated by autologous chemotaxis. Cancer Cell. 11(6): 526-538. Highlighted in: Research Roundup, J Cell Biol. 2007 Jun 18; 177:6 and Cell migration gateway: http://www.cellmigration.org/cmg_update/2007/070701/full/cmg050.shtml
J Goldman*, JM Rutkowski*, JD Shields*, H Schmökel, M Pasquier, Y Cui, D Hinklin, SE Wiley, B Pytowski, and MA Swartz (2007). Co-operative and redundant roles of VEGFR-2 and VEGFR-3 signaling in lymphangiogenesis. FASEB J. 21(4):1003-12.
JD Shields, ME Emmett, DO Dunn, KD Joory, A Orlando, PS Mortimer and DO Bates (2007). Melanoma cell migration towards lymphatics: A mechanism underlying metastasis. Oncogene. 26(21):2997-3005.
JD Shields, M Borsetti, H Rigby, SJ Harper, PS Mortimer, JR Levick, A Orlando, DO Bates (2004). Lymphatic density and metastasis in human malignant melanoma. Br J Cancer. 90(3):693-700.
DO Bates, T Cui, JM Doughty, M Winkler, M Sugiono, JD Shields, D Peat, D Gillatt, SJ Harper (2002). VEGF165b – an inhibitory splice variant of vascular endothelial growth factor is downregulated in renal cell carcinoma. Cancer Res. 62(14), 4123- 31.
BOOK CHAPTERS
J.D Shields. Lymph and Lymphatic Capillaries in Cancer. Immunology of the lymphatic system. Edited by Laura Santambrogio. Springer
JD Shields and MA Swartz. Physiology of the lymphatic vasculature in healthy tissues and cancer. Lymphangiogenesis in Cancer Metastasis. Edited by M. Achen and S. Stacker. Springer