SHIELDS LAB

Check out our review discussing how the tumour microenvironment changes during tumour development from containment to promotion.

Check out our review discussing how stroma regulates lymphatic function in the tumour microenvironment, part of a special lymphatic focussed issue of Advanced Drug Delivery Reviews.

Super exciting to play a small part in this paper, with Tim Halim at the CRUK CI. They show that activation of lung-resident group 2 innate lymphoid cells (ILC2s) orchestrated suppression of natural killer (NK) cell-mediated innate antitumor immunity, leading to increased lung metastases and mortality and reveal that interleukin (IL)-33-dependent ILC2 activation in the lung is involved centrally in promoting tumor burden.

Super exciting to be part of this collaboration with Sarah Teichmann, Klaus Okkenhaug, and David Adams. We demonstrate the ability of T cells to produce steroids, via cyp11a1, to evade anti-tumor immunity, and show that genetic ablation of T cell steroidogenesis restricts primary tumor growth and metastasis. T cell de novo steroidogenesis represents a mechanism of anti-tumor immunosuppression and a potential druggable target.

After a difficult few months of COVID-induced isolation and work from home, the Hutchison/MRC Research Centre and Shields Lab are back in business! It's going to be a slow, careful start, but its a start. The Hutch Core team have been instrumental in getting us back safely. Thanks guys!

We demonstrate the increasing heterogeneity within the stroma as a tumor develops, showing that T cell activation occurs at the tumor following recruitment from lymph nodes and revealing the presence of three dynamic stromal populations that display unique functional properties. Super exciting to collaborate with Sarah Teichmann at the EMBL/EBI Wellcome Trust Sanger Institute. Check it out!

Jacqui and Hafsa travelled to Vancouver Island to join the Keystone Symposia on Stomal Cells in Disease. Jacqui presented our newest data in the field of single cell sequencing exploring the landscape of evolving tumour stroma. Hafsa talked about her exciting findings on Neutrophil-CAF crosstalk.

We are recruiting! Looking for a talented Post Doctoral Research Associate to join us investigating stromal mediated mechanisms of immune dysfunction in the developing tumour.

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Closing date: 23rd February 2020

Sarah successfully defended her PhD, making her the Second Dr. out of the Shields Lab!!! Whoop!

Welcome to Leonor Nunes Rodrigues, PhD Candidate! 

Super exciting to be part of this collaboration with Sarah Teichmann at the EMBL/EBI Wellcome Trust Sanger Institute. Exploiting single cell transcriptomics of regulatory T cells to identify tissue specificities and trajectories of adaptation. Check it out!

Welcome to Corrado Mazzaglia, PhD Candidate! Corrado joins us on a WD Armstrong Award, Joint with Dr Shery Huang, Lecturer in Bioengineering

Welcome back to Will Moody, PhD Candidate!

Super exciting to be part of this collaboration with Ben Hall of our very own MRC Cancer Unit. Exploring the role of stromal osmoregulation in cancer and disease using executable modelling. Check it out!

New work from James Arnold and his team at the Tumour Immunology Group, Kings College London.  Macrophages are exploited from an innate wound healing response to facilitate cancer metastasis. Exciting to be a part of this new work

Jennifer successfully defended her PhD, making her the first Dr. out of the Shields Lab!!! Whoop!

Jacqui presented our newest data in the field of single cell sequencing at the AACR Annual Meeting Chicago; exploring the landscape of evolving tumour stroma

​Check out our new paper in Nature communications.

​Welcome to Melissa Van Velthoven, Masters Student visiting from Utrecht. Melissa will be working on microfluidics platforms to model the tumour microenvironment. Welcome Melissa!

The Shields lab Smash it at the Institute Annual Retreat, held this year at the Moller Centre. Garrett Beeghly took home the runner-up poster prize and Sarah Davidson won the award for best oral presentation. Well done Sarah and Garrett!!!!

Welcome to Carlo Zimarino, PhD Candidate!

Welcome to Will Moody, Part II Student!

The MRC Cancer Unit is going 21st century! Check us out on our very own YouTube channel. Find out about the Shields Lab and explore in 360

Welcome to Garrett Beeghly who joins us from The University of Virginia! Garrett was awarded a prestigious Whitaker Fellowship to support his research in Biomedical Engineering

It was a sad day in the lab....Today Angi said goodbye, leaving us after a fantastic 3.5 years. We wish you the very best of luck at DKFZ, we will miss you. THANK YOU FOR BEING PART OF OUR LAB!!!!

Jennifer Harris and Hafsa Munir present posters at the joint UKAS and British Microcirculation meeting in Birmingham. Stick it the them!

Members of the Shields Lab will be taking part in Cambridge Science Festival. Talks, exhibitions and hands on experiences.....Science boffins communicating the importance of cancer research to the Cambridge Massive!

Welcome to James Jones, Academic Clinical Fellow!

The Shields lab Smash it winning both poster and presentation prizes at the Institute annual Retreat, held this year at the Moller Centre. Well done Sarah and Jennifer!!!!

The First ELRIG Networking event to be held in Cambridge. A great innovation to link Academia and Industry focussing on developing solutions for unmet scientific or technical challenges.

We are seeking motivated PhD candidates for a to join the Shields starting October 2017. Check out the ad.

Welcome to Jonathan Swietlik, Erasmus funded Researcher!

MRC blog highlghts our recent work!

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Check out our first paper in Nature Immunology. Congrats Angi!!

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Jacqui speaks at the first Lumps and Bumps Conference in Nottingham, bridging placental biology and cancer!

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Welcome to Hafsa Munir, Research Associate!

Seeking enthusiastic post docs for a Research Associate Position. See Join us page and MRC Cancer Unit website for details

Jacqui speaks at the first Stromal Immunology Keystone live from Keystone, CO!

Welcome to Sarah Davidson, MRC DTA PhD Student!